HIGHLIGHTS
- who: Heike Chauvistru00e9 from the (UNIVERSITY) have published the article: Persister state-directed transitioning and vulnerability in melanoma, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 24/03/2016
- what: The authors have systematically investigated (i) the actual differentiation phenotype of the KDM5Bhigh melanoma persister state, (ii) the consequences of forcing melanoma cells to ectopically express KDM5B at high levels without the chance to spontaneously revert to normal expression heterogeneity and_(iii) whether KDM5B-directed cell state transitioning can be used as a therapeutic vulnerability. The authors aimed to quantitate this by immunostaining of intercellular . . .
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