HIGHLIGHTS
SUMMARY
Next, the persulfidated form of DJ-1 was obtained by reacting purified wt DJ-1 with various sulfane sulfur donors, since the reduction of the activated disulfide bond formed from C106 and DTP by sodium hydrosulfide had failed. Under these conditions, DJ-1 is selectively persulfidated at C106, as confirmed by the weak reactivity of the C106S mutant with sodium disulfide. This, however, contrasts with the observations suggesting that the mutant protein is also endogenously persulfidated in E. coli, even if the persulfidation of endogenous YajL, a member from the DJ-1 superfamily from . . .
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