Perturbation of autophagy by a beclin 1-targeting stapled peptide induces mitochondria stress and inhibits proliferation of pancreatic cancer cells

HIGHLIGHTS

• who: Na Li et al. from the Shenzhen Research Institute, Polytechnic University, Shenzhen, China have published the research work: Perturbation of Autophagy by a Beclin 1-Targeting Stapled Peptide Induces Mitochondria Stress and Inhibits Proliferation of Pancreatic Cancer Cells, in the Journal: Cancers 2023, 953 of /2023/
• what: The authors show that a (Tat-SP4) developed in the lab further enhanced autophagy in multiple cell lines possessing high basal autophagy activity. The authors reason this unique feature could be exploited to modulate autophagy in PDAC for therapeutic benefit. The study shows that perturbation of the . . .
  

   

  

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