HIGHLIGHTS
SUMMARY
Emerging from this initial research on hydroxyalkenals, the biological aspects of oxidative stress, lipid peroxidation (LPO) and especially "the cell biology of HNE" became an essential focus in Peter Eckl` s scientific interests, with several lines of investigation converging in this central context. This research revealed a high sensitivity of cECs to HNE, with concentrations ≥ 1µM exerting a significant genotoxic effect. Experiments using in_vitro models for oxidative stress (ischemia/reoxygenation, application of redoxcycling Dimethoxy-1,4-naptoquinone) demonstrated that the genotoxicity exerted by these pro-oxidant regimens in cECs is accompanied by the . . .
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