Pfkfb3 controls acinar ip3r-mediated ca2+ overload to regulate acute pancreatitis severity

HIGHLIGHTS

• What: The authors evaluate the biological function of phosphofructo-2kinase/fructose-2 6-biphosphatase 3 (PFKFB3) in AP pathogenesis in 2 independent genetically engineered mouse models of AP. The authors provide evidence for the role of phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) as a regulator of severity in alcohol-related AP. The authors show that PFKFB3 expression is 1 increased in AP and SAP. Because of the central role of glycolysis as one of the main sources of ATP in acinar cells under physiological and disease conditions , the authors focused the studies on PFKFB3 . . .
  

   

  

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