Pfkfb4 interacts with icmt and activates ras/akt signaling-dependent cell migration in melanoma

HIGHLIGHTS

• who: Méghane Sittewelle et al. from the Université Paris-Saclay, Faculté des Sciences d'Orsay, CNRS UMR, INSERM, Orsay, France, INSERM, Orsay, France have published the article: PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma, in the Journal: (JOURNAL)
• what: Using human metastatic melanoma cell lines with high PFKFB4 expression (Rambow et al, 2015), the authors show that PFKFB4 activity is required for active cell migration in several different cellular contexts, without a connection to the rate of glycolysis. In sum, the study has demonstrated a novel, glycolysis . . .
  

   

  

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