HIGHLIGHTS
- who: Rita Berisio and Giovanni Delogu from the Institute, Olbia, Italy have published the paper: PGRS domain structures: Doomed to sail the mycomembrane, in the Journal: (JOURNAL)
- what: In the docking model the authors propose, the PGRS domain of PE_PGRS33 interacts with the externally exposed amino_acids located in the proximity of the hydrophobic ligand-binding pocket of TLR2 (Fig 2), without hindering the binding of the classical TLR2 ligands to the hydrophobic pocket.
SUMMARY
Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. AlphaFold as . . .
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