Ph-dependent compaction of the intrinsically disordered poly-e motif in titin

HIGHLIGHTS

  • who: Sophia Manukian and collaborators from the Department of Chemistry, University of Massachusetts Lowell, Lowell, MA, USA have published the research work: pH-Dependent Compaction of the Intrinsically Disordered Poly-E Motif in Titin, in the Journal: Biology 2022, 1302 of /2022/
  • what: The aim of this study was to understand more about how the intervening_sequence between charged residues impacts the pH-dependent change in intrinsically disordered proteins. For this study, a total of seven peptides were designed to test the effect of uncharged amino_acids on IDR`s pH sensitivity, which included a reference sequence . . .

     

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