Ph profiles of 3-chymotrypsin-like protease (3clpro) from sars-cov-2 elucidate its catalytic mechanism and a histidine residue critical for activity

HIGHLIGHTS

• who: Kenana Al Adem from the Science Division, New York University Abu Dhabi, Abu Dhabi, United Arab have published the research: pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity, in the Journal: (JOURNAL)
• what: The authors identified key residues in the active_site of SARS-CoV-2 3CLpro that interact with the substrate, in addition to the catalytic dyad His41 and Cys145. The work demonstrates that hydrogen_bonding interactions between His163 (at Nu03b5) with the side chain carbonyl oxygen of P1 Gln . . .
  

   

  

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