Ph-responsive lipid nanoparticles achieve efficient mrna transfection in brain capillary endothelial cells

HIGHLIGHTS

  • who: Yu Sakurai and collaborators from the Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai, Japan have published the research work: pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells, in the Journal: Pharmaceutics 2022, x of 27/07/2022
  • what: The authors report herein on the development of lipid nanoparticles (LNPs) in which is encapsulated in a nano-sized capsule composed of a pH-activated and reductive environmentresponsive lipid-like material (ssPalm). The authors attempted to apply the ssPalm . . .

     

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