Phactr1, a coronary artery disease risk gene, mediates endothelial dysfunction

HIGHLIGHTS

• who: Xiaoxuan Ma and colleagues from the Temple University, United States have published the research: PHACTR1, a coronary artery disease risk gene, mediates endothelial dysfunction, in the Journal: (JOURNAL)
• what: PHACTR1 interactomics in TNF-ainduced HUVECs Next, the authors aim to explore the potential molecular mechanism whereby PHACTR1 triggers endothelial dysfunction. Considering Atorvastatin has superior effects on lipid-lowering and cardiovascular protection, the authors focused on evaluating the effect of Atorvastain on PHACTR1 gene_expression . The study demonstrates the role of PHACTR1 in endothelial dysfunction, in terms of endothelial inflammation and endothelial NO production by activating . . .
  

   

  

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