HIGHLIGHTS
- who: Yanjun Cui and colleagues from the Shijiazhuang, China have published the article: Pharmacokinetic Interactions between Canagliflozin and Sorafenib or Lenvatinib in Rats, in the Journal: Molecules 2022, 5419 of 24/08/2022
- what: The authors developed an ultra-performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determination of canagliflozin, sorafenib, and lenvatinib concentrations, and investigated the pharmacokinetic interactions between canagliflozin and sorafenib or lenvatinib in rats.
- how: The extraction efficiency of the different extractants was compared and the results showed that sorafenib was extracted well in methyl tert . . .
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