Pharmacokinetics and tolerability of the dual torc1/2 inhibitor sapanisertib in combination with the mek inhibitor trametinib in dogs

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  • who: Bih-Rong Wei from the Benha University, Egypt Mu00e9xico, Mexico have published the Article: Pharmacokinetics and tolerability of the dual TORC1/2 inhibitor sapanisertib in combination with the MEK inhibitor trametinib in dogs, in the Journal: (JOURNAL)
  • what: In this study, combined inhibitor tolerability and plasma pharmacokinetics was examined, compared to single agents, in healthy laboratory dogs during short-term repeat dose oral administration. The study was not designed to incorporate Good Laboratory Practices (GLP) regulatory criteria. The cumulative evidence from foregoing studies as well as data in this study indicate the dose and . . .

     

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