Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry

HIGHLIGHTS

  • who: November and collaborators from the Xinjiang, China have published the research work: Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry, in the Journal: (JOURNAL)
  • what: In the study , a sensitive and efficient UHPLC-MS/MS method was developed to quantify curcumol in rat plasma and tissue samples. The high plasma_protein binding of curcumol may be the main reason for its rapid distribution and elimination in rats after oral administration.
  • how: The results showed that curcumol was stable for 12 h at room . . .

     

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