Pharmacologic inhibition of reactive gliosis blocks tnf-α-mediated neuronal apoptosis

HIGHLIGHTS

• who: Izhar Livne-Bar from the DepartmentUniversity Health Toronto, Toronto, Ontario, Canada have published the research work: Pharmacologic inhibition of reactive gliosis blocks TNF-u03b1-mediated neuronal apoptosis, in the Journal: (JOURNAL)
• what: To adapt the model for this purpose, the authors first set out to reproduce and expand the previously reported results. To explain these results the authors show that IF inhibition blocked p38 MAPK phosphorylation, and p38-dependent secretion of TNF-u03b1.
• how: For the present series of experiments the authors utilized a well-established excitotoxic model of inner retinal injury . . .
  

   

  

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