Pharmacological activation of atf6 remodels the proteostasis network to rescue pathogenic gabaa receptors

HIGHLIGHTS

• who: Meng Wang from the Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Euclid Ave, Cleveland, OH, USA have published the research: Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors, in the Journal: (JOURNAL)
• what: The authors demonstrate that pharmacologically enhancing endoplasmic reticulum (ER) proteostasis using small molecule activators of the ATF6 (Activating Transcription Factor 6) signaling arm of the unfolded protein response (UPR) increases the assembly trafficking and surface expression of variant G u00ad ABAA receptors. This experiment showed that AA147 and AA263 attenuated the . . .
  

   

  

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