HIGHLIGHTS
- who: Jia Wen et al. from the Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA have published the article: Pharmacological Inhibition of S100A4 Attenuates Fibroblast Activation and Renal Fibrosis, in the Journal: Cells 2022, 2762 of /2022/
- what: This study examined the functional role of S100A4 in regulating TGF-u03b2/Smad3 signaling in fibroblast activation and kidney fibrosis development. In cultured kidney fibroblasts, the authors show that S100A4 functions as a coactivator of TGF-u03b21/Smad3 to promote fibroblast activation. To determine the biological function of S100A4 inhibition . . .
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