Pharmacological inhibition of smyd2 protects against cisplatin-induced acute kidney injury in mice

HIGHLIGHTS

• who: . and colleagues from the Hong Kong University of Science and Technology, Hong Kong SAR, China have published the paper: Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice, in the Journal: (JOURNAL)
• what: The authors investigated the effect of SMYD2 inhibition on the development of AKI induced by cisplatin in a mouse model by using AZ505, a substrate-competitive inhibitor that binds the peptide-bind in groove of SMYD2 to reduce its methyltransferase activity (Ferguson et_al, 2011).
• how: These data indicated that cisplatin at toxic dose enhances SMYD2 . . .
  

   

  

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