Pharmacological modulation of tspo in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease

HIGHLIGHTS

• who: Marta Vicente-Rodru00edguez from the (UNIVERSITY) have published the research work: Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease, in the Journal: (JOURNAL) of 10/05/2022
• what: The authors show that the selective CSF1R inhibitor JNJ-40346527 (JNJ527) attenuated the disease-dependu2011 ent increase in TSPO signal particularly in the dentate gyrus of the hippocampus where JNJ527 attenuated the number of Iba1+ microglia and neurons but not GFAP+ astrocytes or endothelial cells. The authors demonstrate that although TSPO overexpression in the ME7 brains was . . .
  

   

  

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