HIGHLIGHTS
- who: G protein coupled receptor and colleagues from the Monash University, Australia have published the paper: Pharmacological Programming of Endosomal Signaling Activated by Small Molecule Ligands of the Follicle Stimulating Hormone Receptor, in the Journal: (JOURNAL)
- what: The authors took advantage of LMW FSHR ligands from two distinct chemical classes, to assess whether these compounds could alter receptor endosomal signaling via impacting its trafficking compared to FSH. The authors demonstrate that LMW agonistic compounds exhibit enhanced endosomal signaling and recycling due to a differential sensitivity to APPL1 regulation. By using previously reported and novel LMW . . .
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