Pharmacy and drug development optimization and validation of glycerol-induced acute renal failure model in rats in predicting the pharmacokinetics in patients with acute renal failure

HIGHLIGHTS

  • who: USER from the Department of Pharmacology, AUCollege of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India. have published the paper: Pharmacy and Drug Development Optimization and Validation of Glycerol-induced Acute Renal Failure Model in Rats in Predicting the Pharmacokinetics in Patients with Acute Renal Failure, in the Journal: (JOURNAL) of May/11,/2009
  • what: Drug attrition in late phase clinical development or postmarketing stage causes a serious economic problem to the pharmaceutical industries and unfavorable pharmacokinetic properties are one of the major reasons for this. The authors aimed to optimize a rat model . . .

     

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