Phase separation of α-crystallin-gfp protein and its implication in cataract disease

HIGHLIGHTS

• who: Jie Shi from the Departmentsen University, Guangzhou, Guangdong, China have published the research work: Phase separation of u03b1-crystallin-GFP protein and its implication in cataract disease, in the Journal: Scientific Reports Scientific Reports
• what: The authors demonstrated that u03b1-crystallin-GFP proteins formed aggregates via a phase separation mechanism.

SUMMARY

To examine whether crystallin proteins underwent phase separation, members of the crystallin-GFP proteins were ectopically expressed in SRA01/04 cells, an immortalized human lens epithelial_cell line. Interestingly, only αA- and αB-crystallin-GFP formed high concentrated puncta, whereas . . .

 



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