Phase separation of the c. elegans polycomb protein sop-2 is modulated by rna and sumoylation

HIGHLIGHTS

• who: Wenyan Qu from the the IDR of SOP-2, droplets formed by sumoylated , (IDR K R K R) were still larger in size and more dynamic compared to the non-modified protein (FigS, D and S, I). In living animals, compared to wild-type SOP-2:: GFP, SOP-2(K R K R)::GFP bodies were smaller and also displayed a more diffuse GFP signal (Fig. , K). In conclusion, we showed here that the C. elegans PcG protein , undergoes LLPS. The IDR region mediates LLPS of SOP-2, which is modulated by post-translational sumoylation. Oligomerization . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.