HIGHLIGHTS
- who: Vincent Spegg from the (UNIVERSITY) have published the research work: Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres, in the Journal: (JOURNAL) of 31/01/2022
- how: The results are consistent with these observations and suggest that nuclear RPA condensates provide a reservoir of highly concentrated free RPA in excess over the bound ssDNA which enables rapid exchange of RPA molecules on the enclosed ssDNA.
- future: Studies employing dedicated assays to interrogate ALT sub-pathway usage will be needed to investigate this hypothesis.
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