Phenome-wide analysis of genome-wide polygenic scores

HIGHLIGHTS

• who: E Krapohl from the Association statistics for dozens of large meta-analytic GWAS are now available, including GWAS for psychiatric and cognitive traitsThe GPS based on these GWAS results are limited by the ‘hidden heritability' ceiling and, as yet, they account for only a few percent of the variance or liability of their target trait [2]. In addition, most GWAS are based on comparisons between diagnosed cases versus controls using a liability model that assumes continuous liability throughout the population, but the extent to which these case/control results generalize to prediction of continuous traits in . . .
  

   

  

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