HIGHLIGHTS
- who: Ilija N. Cvijetiu0107 and colleagues from the Faculty of Chemistry, University of Belgrade, Studentski trg, Belgrade, Serbia have published the article: Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase II, in the Journal: Pharmaceuticals 2023, 341 of /2023/
- what: The authors focused on the most promising thiocarbohydrazone, compound 2, from the initial HTS assay and performed a topo IIu03b1-mediated decatenation assay together with etoposide as a reference molecule. The authors evaluated that compound 2 is a catalytic inhibitor of human DNA topoisomerase IIu03b1.
- how: The . . .
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