Phenotypic screening identifies modulators of amyloid precursor protein processing in human stem cell models of alzheimer’s disease

HIGHLIGHTS

• who: Philip W. Brownjohn from the Gurdon Institute University of Cambridge, Cambridge , QN, UK have published the research work: Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease, in the Journal: (JOURNAL) of April/11,/2017
• what: This study shows feasibility of phenotypic drug screening in human stem cell models of Alzheimer-type dementia and points to possibilities for indirectly modulating APP processing independently of g-secretase modulation. The authors report here a phenotypic screen of small_molecules in cortical neurons with a genetic form of AD . . .
  

   

  

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