Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia

HIGHLIGHTS

• who: François Vergez from the elucidating cancer biology and identifying diagnostic and predictive biomarkers [14, ]However, there are still very few clinically relevant biomarkers and disease subtypes that have been identified by these approaches [16-18]. Here, we did a phenotypic, cytogenetic, and molecular correlative analysis of a very large cohort of AML patients to capture the AML surfaceome that appears to be caused by the stage of leukemia arrest (SLA) and by specific genomic features. We hypothesized that our approach may add to current AML classifications by identifying relevant phenotypic AML subtypes with specific clinical . . .
  

   

  

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