Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity

HIGHLIGHTS

• who: T. Tristan Brandhorst from the Departments of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI have published the paper: Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity, in the Journal: Cys 75 of 19/Oct/2018
• what: The authors show that the drug interferes with triosephosphate isomerase (TPI) causing release of methylglyoxal (MG). The authors report that the Drk1 HHK responds to aldehydic stress induced by elevated cytosolic methylglyoxal (MG) upon fludioxonil treatment. The authors show that fludioxonil treatment both inhibits . . .
  

   

  

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