Phf6 expression levels impact human hematopoietic stem cell differentiation

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  • who: Tom Taghon from the United States The University of Manchester have published the article: PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation, in the Journal: (JOURNAL)
  • what: The authors show dynamic regulation of PHF6 during normal human hematopoiesis and the requirement of controlled PHF6 expression to ensure normal hematopoietic lineage differentiation. The authors show that PHF6 knockdown during T_cell development in human in_vitro and in zebrafish in_vivo modulates NOTCH1 expression and its downstream signaling activity, further supporting a functional Frontiers in Cell and Developmental Biology | www.frontiersin.org The authors show that PHF6 . . .

     

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