HIGHLIGHTS
- who: Annalisa D`Avola and collaborators from the Centre Queen Mary University of, London, United Kingdom have published the paper: PHGDH is required for germinal center formation and is therapeutic target in MYC-driven lymphoma The Francis Crick, in the Journal: (JOURNAL)
- what: The authors demonstrate that upregulation of a functional serine synthesis pathway is a metabolic hallmark of B cell activation and the germinal center reaction. Taken together, this work provides important evidence that PHGDH is a viable target for the treatment of pathological B cell proliferation, either for the modulation of humoral immunity . . .
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