HIGHLIGHTS
- who: Frank S. Choveau from the (UNIVERSITY) have published the paper: Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains, in the Journal: (JOURNAL) of August/15,/2018
- what: The authors show models of the VSD, PD, and S6Jx based on the coordinates of the Kv1.2 channel solved in the activated/open conformation . The authors investigate the molecular determinants involved in the regulation of KCNQ3 channels by PIP2. The present work, reporting that Arg364 and His367 mutations of KCNQ3T, corresponding to R325A and H328C in KCNQ2, are . . .
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