Phospho-dependent regulation of samhd1 oligomerisation couples catalysis and restriction

HIGHLIGHTS

• who: Laurence H. Arnold et al. from the Institute for Human Development, Faculty of Medicine and Human Sciences, University of Manchester, Manchester, United Kingdom have published the paper: Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction, in the Journal: (JOURNAL)
• what: Based on the findings the authors propose model for phosphorylationdependent regulation of activity where dephosphorylation switches housekeeping found in cycling cells to high-activity stable tetrameric form that depletes and maintains low levels of dNTPs in differentiated cells. The authors demonstrate that both the HD domain and CtD are required for restriction . . .
  

   

  

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