Phosphonates and phosphonate prodrugs in medicinal chemistry: past successes and future prospects

HIGHLIGHTS

  • who: GCPII et al. from the Institute of Organic and Biochemistry, Academy of Sciences of the Czech Republic (ASCR), Prague, Czechia, Neuroscience, Medicine, Oncology, Johns Hopkins Drug Discovery, Baltimore, MD, United States University of Eastern Finland, Finland have published the research work: Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects, in the Journal: (JOURNAL)
  • what: In this review the authors focus on two groups of biologically active phosphonates.
  • how: The synthesis of PMEA (adefovir) according to this procedure is described in Figure 3. The compound was tested in adult . . .

     

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