Phosphorylation of muramyl peptides by nagk is required for nod2 activation

HIGHLIGHTS

• who: Che A. Stafford from the (UNIVERSITY) have published the paper: Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation, in the Journal: (JOURNAL) of 19/02/2021
• what: The authors show that the amino sugar kinase NAGK phosphorylates MDP at the hydroxyl group of the C6 position of its MurNAc moiety.
• how: Using a forward genetic screen to identify factors required for MDP detection the authors identified N-acetylglucosamine kinase (NAGK) as being essential for the immunostimulatory activity of MDP. The authors obtained analogous results when measuring NF-u03baB activity . . .
  

   

  

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