Phosphorylation of tau at y18, but not tau-fyn binding, is required for tau to modulate nmda receptor-dependent excitotoxicity in primary neuronal culture

HIGHLIGHTS

• who: Takashi Miyamoto from the Gladstone Institute of Neurological Disease, Owens Street, San Francisco, CA, USA Department of Neurology, University of California, San Francisco, San have published the paper: Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture, in the Journal: (JOURNAL)
• what: The authors demonstrate that shRNA-mediated knockdown of reduces glutamate-induced NMDA receptordependent Ca2+ influx and neurotoxicity in neurons from wildtype mice. To determine whether tau-Fyn interactions are involved in the tau-dependent modulation of excitotoxicity . . .
  

   

  

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