Phosphorylation of xpd drives its mitotic role independently of its dna repair and transcription functions

HIGHLIGHTS

• who: Emmanuel Compe and colleagues from the (UNIVERSITY) have published the article: Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions, in the Journal: (JOURNAL) of 17/08/2022
• what: The authors show that during mitosis, XPD localizes differently to other TFIIH subunits and that it interacts with Eg5, a motor kinesin protein required for establishing bipolar spindle . To Eg5, the authors show that NEK6 phosphorylates XPD at its threonine-425 (T425) residue, which promotes the association of XPD with the CAK module of TFIIH, revealing a fine-tuned . . .
  

   

  

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