Pht427 as an effective new delhi metallo-β-lactamase-1 (ndm-1) inhibitor restored the susceptibility of meropenem against enterobacteriaceae producing ndm-1

HIGHLIGHTS

• who: Xiaohui Li from the Zhejiang University, China have published the research: PHT427 as an effective New Delhi metallo-u03b2-lactamase-1 (NDM-1) inhibitor restored the susceptibility of meropenem against Enterobacteriaceae producing NDM-1, in the Journal: (JOURNAL) of 17/04/2023
• what: In this study, PHT427 (4-dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide) was identified as a novel NDM-1 inhibitor and restored the susceptibility of meropenem against Enterobacteriaceae producing NDM-1.
• how: The results showed that PHT427 could bind to NDM-1 with a KD value of . . .
  

   

  

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