Physiological and toxic effects of purine intermediate 5-amino-4-imidazolecarboxamide ribonucleotide (aicar) in yeast*

HIGHLIGHTS

• who: Hans C. Hürlimann from the (UNIVERSITY) have published the Article: Physiological and Toxic Effects of Purine Intermediate 5-Amino-4-imidazolecarboxamide Ribonucleotide (AICAR) in Yeast*, in the Journal: (JOURNAL) of May/19,/2011

SUMMARY

There are multiple examples where AICAr effects were partially or fully AMP-dependent kinase-independent. In human, severe symptoms are associated with AICAR transformylase inosine monophosphate cyclohydrolase deficiency, a defect leading to accumulation of AICAR and derivatives. PCR products were digested with BamHI and NsiI and cloned in the pCM189 vector digested with BamHI and PstI, resulting . . .

 



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