HIGHLIGHTS
- who: Chemoprevention and collaborators from the Graduate School of Biomedical Science, Nagasaki UniversityJapan have published the research: Phytochemicals Oxidative & electrophilic stresses, in the Journal: (JOURNAL)
- what: The authors provide information about phytochemicals which activate Nrf2, and examples of Nrf2 activation-mediated detoxication of xenobiotics.
SUMMARY
Electrophiles have higher toxicity because of their ability for covalent modification to endogenous nucleophiles such as thiol groups or amino groups of proteins (Kumagai and amp; Abiko, 2017, Lopachin et_al, 2012). Cys151, Cys273, and Cys288 are known to be the highly reactive Cys among the 27 . . .
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