HIGHLIGHTS
SUMMARY
Plasma concentrations of total PSs (mainly the sum of sitosterol and campesterol) are generally between 7-24 µmol/L (0.3-1.0 mg/dL), which is approximately 500-fold lower than circulating concentrations of total cholesterol; subsequently, PSs account for less than 1% of total plasma sterols. Genetic variations in sterol transporters, which cause increased plasma concentrations of PSs, not only result in higher uptake and higher plasma concentrations of PSs but also in pleiotropically increased intestinal cholesterol absorption and subsequently higher plasma concentrations of LDL-C. Taken together, the LDL-C lowering . . .
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