HIGHLIGHTS
SUMMARY
The authors proposed a model (the "odontoblast hydrodynamic receptor theory/model"; Shibukawa et_al, 2015) which suggests that intercellular odontoblast-neuron signal_transduction explains the sensory generation mechanism of dentinal pain. In this model, mechanical stimulation of odontoblasts resulting from deformation of the odontoblastic membrane by dentinal fluid movement (via hydrodynamic force inside dentinal tubules) induced transmembrane Ca2+ influx via activation of transient receptor potential (TRP)-vanilloid subfamily member-1, -2, and -4 (TRPV1, TRPV2, TRPV4); TRP-ankyrin subfamily member-1 (TRPA1) (Shibukawa et_al, 2015); and Piezo1 channels (Sato et_al, 2018; Matsunaga et_al, 2021), all of . . .
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