Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice

HIGHLIGHTS

• who: Jonathan Madar from the Piezo2-Cre mice with RC::L-hM Dq mice (JAX Stock #, ) have published the Article: Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice, in the Journal: (JOURNAL) of 15/03/2022
• what: The authors show that chemogenetic activation or nociceptor-targeted deletion of Piezo2 is sufficient to regulate colonic mechanical sensitivity in a sex dependent manner. This study reveals a previously uncharacterized phenomenon that Piezo2 expressed in nociceptive neurons demonstrates sexual dimorphism in the mediation of colonic mechanosensing. The authors reason that the higher level of . . .
  

   

  

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