Pigr and pecam-1 bind to pneumococcal adhesins rrga and pspc mediating bacterial brain invasion

HIGHLIGHTS

• who: Br ief Definitive Repor and colleagues from the DepartmentKarolinska University have published the Article: pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion, in the Journal: (JOURNAL) of 30/09/2022
• what: The authors show that the major adhesin of the pneumococcal pilus-1 RrgA binds both receptors whereas the choline binding protein PspC binds but to a lower extent only pIgR. The authors show that treatment with blocking antibodies targeting the two receptors, before or after pneumococcal challenge, protects mice from pneumococcal entry into the brain. As . . .
  

   

  

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