Pigs with an point mutation derived from zygotes electroporated with crispr/ cas9 and ssodn

HIGHLIGHTS

• who: January and collaborators from the Chulalongkorn University, Thailand have published the Article: Pigs with an point mutation derived from zygotes electroporated with CRISPR/ Cas9 and ssODN, in the Journal: (JOURNAL)
• what: The authors simultaneously introduced Scr7 with CRISPR/Cas9 and ssODN into porcine zygotes to improve the efficiency of point mutation introduction. The authors designed gRNAs using the COSMID webtool to minimize off-target effects.
• how: To minimize the off-target effects and improve practical gene editing the latest approaches were developed including off-target detection by algorithmically-designed software and genome . . .
  

   

  

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