Pink1/parkin pathway activation for mitochondrial quality control – which is the best molecular target for therapy?

HIGHLIGHTS

• who: Laura F. Silvian from the Biogen, Cambridge, MA, United States Central Michigan University have published the research: PINK1/Parkin Pathway Activation for Mitochondrial Quality Control - Which Is the Best Molecular Target for Therapy?, in the Journal: (JOURNAL)

SUMMARY

Under oxidative stress and other damaging insults, PINK1 is stabilized in the outer mitochondrial membrane where it first auto-activates by phosphorylation (Okatsu et_al, 2012; Rasool et_al, 2018). It then activates mitophagy by phosphorylation of Ubiquitin (pUb) (Kane et_al, 2014; Kazlauskaite et_al, 2014; Koyano et_al, 2014) as well as Parkin on its Ubl domain . . .

 



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