Pinx1 loss confers susceptibility to parp inhibition in pan-cancer cells

HIGHLIGHTS

• What: In this context, the authors aimed to broaden the comprehension of the biological roles of PARP1 and the applicability of PARP inhibitors Official journal of CDDpress 2 by exploring novel PARP1 interacting proteins. Loss of PINX1 confers susceptibility to PARP inhibition Considering the practical application value of PARPi in cancer therapy, the authors investigate whether any of the three newly identified PARP1 interactors could influence the efficacy of PARP inhibitors. Deletion of PINX1 impairs DNA damage repair Based on the observation of the synergistic effect of PINX1 deficiency and PARP inhibitors, the authors aimed to investigate . . .
  

   

  

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