Pip5 kinases regulate membrane phosphoinositide and actin composition for targeted granule secretion by cytotoxic lymphocytes

HIGHLIGHTS

  • who: Christian M. Gawden-Bone from the Institut e for Medical Research, Cambridge Biomedical Campus, Cambridge , XY, UK have published the research work: PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes, in the Journal: (JOURNAL) of September/18,/2018
  • what: The authors demonstrate immune synapse formation led to rapid localized changes the composition of the plasma both reducing phosphoinositide-4-phosphate (PI(4)P) PI(4 5)P2 and PI(3 4 5)P3 and increasing diacylglycerol (DAG) and PI(3 4)P2 within the first 2 min . . .

     

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