Pit2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in ovx-induced osteoporosis

HIGHLIGHTS

• who: Giulia Frangi from the University of Bristol, United Kingdom have published the Article: PiT2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in OVX-induced osteoporosis, in the Journal: (JOURNAL)
• what: The authors report for the first time a role for PiT2 in the maintenance of bone marrow adipose_tissue volume. The authors show that bone loss is similar in OVX- PiT2+/+ mice and OVX-PiT2-/- mice, indicating that osteoclast formation and activity are not impaired, consistent with the previous findings that showed normal osteoclast activity in PiT2-/- mice .
 



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