Pixel-wise programmability enables dynamic high-snr cameras for high-speed microscopy

HIGHLIGHTS

• What: The authors examine and address the limitations of SNR at high speed by introducing a pixel design and sampling method. The authors demonstrate a CMOS image sensor with pixelwise programmable exposures (PE-CMOS) to take advantage of the highly correlated nature of microscopy scenes. To ensure the PE-CMOS`s interpolation process does not introduce systematic artifacts, the authors examine the interpolation process in detail (Methods), even when interpolating an ROI with pixels of uncorrelated activity. In an ROI with highly correlated pixel outputs, the authors demonstrate that combining the outputs from low-frequency pixels, each . . .
  

   

  

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